Neuropharmacology and Neurochemistry

Synaptic Function and Dysfunction in Brain Diseases

Synaptic dysfunction results in cell-intrinsic molecular mechanism modifications or changes in surrounding biochemical processes. A synaptic dysfunction at an early or late stage is a common denominator of several diseases called synaptopathies. Synaptopathy is a popular term used to define the key characteristics of the psychiatric and neurodegenerative diseases. It suggests that synaptic disorders can be the major determinant of such brain diseases.